A 2019 meta-analysis of girls-only HPV vaccination programs in 14 countries that included more than 60 million vaccinated people showed strong evidence of the vaccine’s effectiveness (9). To learn more, see VFC program. In addition, most of the HPV-positive non-cervical cancers arise in men. Hildesheim A, Herrero R, Wacholder S, et al. Meites E, Szilagyi PG, Chesson HW, et al. Lancet 2019; 394(10197):497-509.Â. HPV vaccination is preventing cancer-causing infections and precancers. Is one dose of human papillomavirus vaccine as effective as three? Should HPV vaccines be given to women who are already infected with HPV or have cervical cell changes? Gardasil 9 prevents infection with the same four HPV types plus five additional cancer-causing types (31, 33, 45, 52, and 58) that together account for 10 to 20% of cervical cancers. New England Journal of Medicine 2006; 354(11):1109–1112. CDC recommends that 11- to 12-year-olds receive two doses of HPV vaccine 6 to 12 months apart. If your doctor does not stock HPV vaccine, ask for a referral. Â. Human papillomavirus vaccination coverage among adolescents, 2007-2013, and postlicensure vaccine safety monitoring, 2006-2014--United States. Durability of protection afforded by fewer doses of the HPV16/18 vaccine: The CVT Trial. Pain, redness, or swelling in the arm where the shot was given, HPV (Human Papillomavirus) Gardasil-9 Vaccine Information Statement (VIS). To date, protection against the targeted HPV types has been found to last for at least 10 years with Gardasil (10), at least 9 years with Cervarix (11), and at least 6 years with Gardasil 9 (12). Human papillomavirus (HPV) is a group of related viruses. Yang A, Farmer E, Wu TC, Hung CF. Giuliano AR, Palefsky JM, Goldstone S, et al. HPV vaccination works extremely well. Vaccine 2011; 29(46):8279-8284. How much does HPV vaccination cost, and will insurance pay for it? Chatterjee A. Another prevention strategy that is being explored is topical microbicides. The best way to know how much vaccination will cost is to contact the insurance plan or the clinic. doi: 10.1093/jnci/djx158. The federal Affordable Care Act (ACA) requires most private insurance plans to cover recommended preventive services (including HPV vaccination) with no copay or deductible. Infectious Diseases 2017; 17(12):1293-1302. Stokley S, Jeyarajah J, Yankey D, et al. On very rare occasions, severe (anaphylactic) allergic reactions may occur after vaccination. Some people should not get some HPV vaccines, including: HPV vaccines are safe for children who are mildly ill – for example, with a low-grade fever of less than 101 degrees, a cold, runny nose, or cough. The American Cancer Society recommends routine HPV vaccination principally for females aged 11 to 12 years, but also for females aged 13 to 18 years to catch up those who missed the opportunity to be vaccinated or who need to complete the vaccine series. Teens and young adults through age 26 years who didn’t start or finish the HPV vaccine series also need HPV vaccination. Since HPV vaccination was first recommended in 2006, there has been a significant reduction in HPV infections. Kreimer AR, Herrero R, Sampson JN, et al. Contemporary Clinical Trials 2018; 68:35-44. HPV vaccine is recommended for routine vaccination at age 11 or 12 years. Some people may feel dizzy or faint after vaccination. Â. Merck, the manufacturer of Gardasil 9, offers the Merck Vaccine Patient Assistance Program, which provides Gardasil 9 for free to people aged 19 to 26 who live in the United States, do not have health insurance, and have an annual household income less than a certain amount. The Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP) develops recommendations regarding all vaccination in the United States, including HPV vaccination. HPV vaccines are highly effective in preventing infection with the types of HPV they target when given before initial exposure to the virus—which means before individuals begin to engage in sexual activity. However, they closely resemble the natural virus, and antibodies against the VLPs also have activity against the natural virus. Journal of the National Cancer Institute 2018; 110(2). Vaccine 2018;36:1781-1788. DeLong G. A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection. People who have an allergy to yeast (Gardasil and Gardasil 9). • HPV vaccination for individuals ages 27 through 45 can be considered based on shared clinical decision making. The most common side effects of HPV vaccine are usually mild and include: Brief fainting spells and related symptoms (such as jerking movements) can happen after any medical procedure, including vaccination. Fewer teens and young adults are getting genital warts. New England Journal of Medicine 2002; 347(21):1645-1651. pii: dju436. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. HPV infects at least 50% of sexually active people at some point in their lives. They provide maximum benefit if a person receives them before he or she is sexually active (24, 25). HPV is a group of more than 200 related viruses, of which more than 40 are spread through direct sexual contact. Gardasil-9 (Merck), a nine-valent HPV vaccine (9vHPV) that protects against HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58, is the only HPV vaccine currently distributed in the U.S. HPV vaccination works extremely well. The vaccines do not prevent other sexually transmitted diseases, nor do they treat existing HPV infections or HPV-caused disease. 2019. Preteens usually get the HPV vaccine at age 11 or 12, though vaccination can start as early as age 9. How is the vaccine given? All vaccines protect against at least HPV types 16 and 18, which cause the greatest risk of cervical cancer. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: Updated systematic review and meta-analysis. The national NHS HPV vaccination programme uses a vaccine called Gardasil. Gee J, Naleway A, Shui I, et al. The HPV vaccine helps protect you against certain types of HPV that can lead to cancer or genital warts. The VLPs have been found to be strongly immunogenic, which means that they induce high levels of antibody production by the body. Herrero R, Quint W, Hildesheim A, et al. Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial. Journal of Biomedical Science 2016; 23(1):75. Perspectives for therapeutic HPV vaccine development. Usual Pediatric Dose for Human Papillomavirus Prophylaxis Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant. VLPs are not infectious because they lack the virus’s DNA. Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). What is HPV? Why is it important for people to follow HPV vaccination recommendations? CDC twenty four seven. The current ACIP (CDC) recommendations for HPV vaccination are as follows (4): The HPV vaccine is given as a series of shots. Naud PS, Roteli-Martins CM, De Carvalho NS, et al. HPV vaccines are vaccines that protect against infection with human papillomaviruses (HPV). Although HPV vaccines have been found to be safe when given to people who are already infected with HPV, the vaccines do not treat infection. Efficacy of a carrageenan gel against transmission of cervical HPV (CATCH): Interim analysis of a randomized, double-blind, placebo-controlled, phase 2B trial. Children who start the vaccine series before their 15th birthday need only two doses to be fully protected. Ongoing clinical trials are testing the safety and efficacy of a therapeutic DNA vaccine to treat HPV-related cervical and vulvar lesions.Â. All three HPV vaccines protect against HPV types 16 and 18 that cause most HPV cancers. What research is being done on strategies to prevent HPV infection? However, there is no known serologic correlate of immunity and … Arnheim-Dahlström L, Pasternak B, Svanström H, Sparén P, Hviid A. Autoimmune, neurological, and venous thromboembolic adverse events after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark and Sweden: Cohort study. A safety review by the FDA and the CDC considered adverse side effects related to Gardasil immunization that have been reported to the Vaccine Adverse Events Reporting System since the vaccine was licensed (19–21). Human papillomavirus vaccines: WHO position paper, May 2017-Recommendations. HPV vaccination is recommended for all preteens (including girls and boys) at age 11–12 years. HPV vaccines are highly immunogenic. The next generation of HPV vaccines: Nonavalent vaccine V503 on the horizon. A 12-year follow-up on the long-term effectiveness of the quadrivalent human papillomavirus vaccine in 4 Nordic countries. People with severe allergies to any component of a vaccine should not receive that vaccine. For example, compared with the period before vaccination began,Â. Preteens and teens need 2 doses of the HPV vaccine as part of their routine vaccine schedule. Not only does vaccination protect vaccinated individuals against infection by the HPV types targeted by the respective vaccine, but also vaccination of a significant proportion of the population can reduce the prevalence of the vaccine-targeted HPV types in the population, thereby providing some protection for individuals who are not vaccinated (a phenomenon called herd immunity). Cervarix and Gardasil are still used in other countries. The Cervarix vaccine has been found to provide partial protection against a few additional HPV types not included in the vaccine that can cause cancer, a phenomenon called cross-protection (8). Clinical Microbiology and Infection 2019; 25(2):210-216.Â. Other HPV vaccines are available outside the U.S. All of these vaccines help … The Lancet. Sampson JN, Hildesheim A, Herrero R, et al. If a single dose of HPV vaccine were effective, that would be an important advance. The rates of adverse side effects in the safety review were consistent with what was seen in safety studies carried out before the vaccine was approved and were similar to those seen with other vaccines. Applies to human papillomavirus vaccine: intramuscular suspension Side effects requiring immediate medical attention Along with its needed effects, human papillomavirus vaccine may cause some unwanted effects. We report on the safety of a quadrivalent vaccine (active against HPV … Gardasil is a single dose injection. Kreimer AR, Gonzalez P, Katki H, et al. Less than 1 in 1,000 people who have the Gardasil HPV vaccine experience: an itchy red rash (hives) Very rare side effects. Among these, two HPV types cause genital warts, and about a dozen HPV types can cause certain types of cancer—cervical, anal, oropharyngeal, penile, vulvar, and vaginal. Yet vaccination rates remain low, and incidence of HPV infection remains high. JAMA 2007; 298(7):743–753. Some people report having very mild side effects, like a sore arm from the shot. All three HPV vaccines protect against HPV types 16 and 18 that cause most HPV cancers. Gardasil is for the prevention of HPV types 6, 11, 16, and 18 infections in girls and women aged 9 to 26 years. Although not all of these side effects may occur, if they do occur they may need medical attention. Gardasil-9 (Merck), a nine-valent HPV vaccine (9vHPV) that protects against HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58, is the only HPV vaccine currently distributed in the U.S. How Well Do These Vaccines Work? Three HPV vaccines are currently available in Belgium with the 9-valent (" 9HPV " - 6/11/16/18/31/33/45/52/58) offering protection against most of HPVassociated diseases. Lancet 2015; 386(10008):2078-2088. They can cause warts on different parts of your body. Medicaid covers HPV vaccination in accordance with ACIP recommendations, and immunizations are a mandatory service under Medicaid for eligible individuals under age 21. Tell your doctor about any severe allergies. The patients who developed blood clots had known risk factors for developing them, such as taking oral contraceptives. Only two doses are recommended if vaccination started at age 9 and through age 14. It can also be given up to age 45 in men who are at … In the trials that led to the approval of Gardasil and Cervarix, these vaccines were found to provide nearly 100% protection against persistent cervical infections with HPV types 16 and 18 and the cervical cell changes that these persistent infections can cause. Journal of the National Cancer Institute 2015; 107(3). The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. HPV infections are so common that nearly all men and women will get at least one type of HPV at some time in their lives. In addition, the rates of HPV infection remain low for at least 7 years (27). PPTX pptx, 180kb Human Vaccines and Immunotherapeutics 2014; 10(8):2147-2162. Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine: Final analysis of a long-term follow-up study up to 9.4 years post-vaccination. Despite a solid safety record for Gardasil and Cervarix, many adverse events have been registered with the Vaccine Adverse Events Reporting System (VAERS). (Vaccination can be started at age 9.) Sitting or lying down when getting a shot and staying in that position for about 15 minutes after a vaccination can help prevent fainting and injuries caused by falls. Gardasil 9 is now the only HPV vaccine available for use in the United States. The first dose is routinely recommended at age 11–12 years old; the series can be started at age 9 years. They get the second dose about 6 to 12 months after the first dose. Harper DM, Nieminen P, Donders G, et al. Less than 1 in 10,000 people who have the Gardasil HPV vaccine experience: difficulty breathing and restriction of the airways; Other side effects. Human papillomavirus (HPV) vaccines are vaccines that prevent infection by certain types of human papillomavirus. Before they could be licensed, all three HPV vaccines were tested for safety and efficacy in tens of thousands of people in the United States and many other countries. Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica. The trials that led to approval of Gardasil 9 found it to be nearly 100% effective in preventing cervical, vulvar, and vaginal disease caused by the five additional HPV types (31, 33, 45, 52, and 58) that it targets (6). Three HPV vaccines—9-valent HPV vaccine (Gardasil® 9, 9vHPV), quadrivalent HPV vaccine (Gardasil®, 4vHPV), and bivalent HPV vaccine (Cervarix®, 2vHPV)—have been licensed by the U.S. Food and Drug Administration (FDA). Gardasil 9 is as effective as Gardasil for the prevention of diseases caused by the four shared HPV types (6, 11, 16, and 18), based on similar antibody responses in participants in clinical studies. In addition, the federal Vaccines for Children Program provides immunization services for children 18 and under who are Medicaid eligible, uninsured, underinsured, receiving immunizations through a Federally Qualified Health Center or Rural Health Clinic, or are Native American or Alaska Native. Our syndication services page shows you how. Journal of Clinical Oncology 2011; 29(32):4294–4301. Design and statistical considerations for studies evaluating the efficacy of a single dose of the human papillomavirus (HPV) vaccine. See the routine vaccination schedule for: : A national cohort analysis. Carrageenan, a compound that is extracted from a type of seaweed and used widely in foods and other products, has been found to inhibit HPV infection in laboratory studies. However, a higher proportion of syncope (fainting) and venous thromboembolic events (blood clots) were seen with Gardasil than are usually seen with other vaccines. Widespread HPV vaccination has the potential to reduce cervical cancer incidence around the world by as much as 90% (8, 12). Saving Lives, Protecting People, HPV Vaccines: Vaccinating Your Preteen or Teen, HPV and Oropharyngeal Cancer – Fact Sheet, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. The vaccine is available from ages 9 to 21 for men. More information is available at https://www.merckhelps.com/GARDASIL%209 or by telephone at 1–800–293–3881. Kjaer SK, NygÃ¥rd M, Dillner J, et al. Koutsky LA, Ault KA, Wheeler CM, et al. The program provides vaccines at no cost to children ages 18 years and younger who are uninsured, Medicaid-eligible, or American Indian/Alaska Native. This allows your body to build almost complete protection against HPV before you have contact with the virus. Vaccination is not recommended for everyone older than age 26 years. A safety review of Gardasil in Denmark and Sweden did not identify an increased risk of blood clots (20). Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. Trimble CL, Morrow MP, Kraynyak KA, et al. HPV is spread through intimate skin-to-skin or sexual contact. Morbidity and Mortality Weekly Report 2014; 63(RR-05):1-30. The HPV vaccine is still effective after sexual activity has begun. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Human Papillomavirus (HPV) Vaccines was originally published by the National Cancer Institute.”. Falls after fainting may sometimes cause serious injuries, such as head injuries. ANSWER The HPV vaccine contains no viruses and is not made from human papillomavirus. doi: 10.1093/jnci/dju436. Gynecologic Oncology 2019; 153(3):521-529.Â, If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. There could be future changes in screening recommendations for vaccinated women. MMWR Morbidity and Mortality Weekly Report 2019; 68(32):698–702.Â, Meites E, Kempe A, Markowitz LE. Human papillomavirus vaccination for adults: Updated recommendations of the Advisory Committee on Immunization Practices. ACIP also recommends vaccination for everyone through age 26 years if not adequately vaccinated previously. Safaeian M, Sampson JN, Pan Y, et al. World Health Organization. Do women who have been vaccinated still need to be screened for cervical cancer? Recommandations générales. The vaccine prevents certain cancers. Why is it important for people to follow HPV vaccination recommendations? Between them, types 16 and 18 are the cause of most cervical cancers in the UK (more than 70%). The most recent safety data review for HPV vaccines continues to indicate that these vaccines are safe (22). Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels. HPV vaccine has also reduced the number of cases of precancers of the cervix in young women. Evidence for single-dose protection by the bivalent HPV vaccine-Review of the Costa Rica HPV vaccine trial and future research studies. Kavanagh K, Pollock KG, Cuschieri K, et al. These can largely be prevented by keeping the person seated for up to 15 minutes after vaccination. The Vaccines for Children (VFC) program helps families of eligible children who might not otherwise have access to vaccines. HPV vaccine has the potential to prevent more than 90% of HPV-attributable cancers. Like other immunizations that guard against viral infections, HPV vaccines stimulate the body to produce antibodies that, in future encounters with HPV, bind to the virus and prevent it from infecting cells. Most private insurance plans cover HPV vaccination. Brotherton JM, Budd A, Rompotis C, et al. Sources. Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States. Further evidence that large-scale HPV vaccination confers protection for unvaccinated individuals comes from a 2019 meta-analysis of girls-only HPV vaccination programs in 14 high-income countries that included 60 million vaccinated people (9). You can also contact your state health department to learn more about where to get HPV vaccine in your community. ACIP recommends that women who have an HPV infection and/or an abnormal Pap test result that may indicate an HPV infection should still receive HPV vaccination if they are in the appropriate age group because the vaccine may protect them against high-risk HPV types that they have not yet acquired. British Medical Journal 2013; 347:f5906. There's no reason to delay vaccination for a mild illness, such as the common cold. Gardasil 9 is an HPV vaccine approved by the U.S. Food and Drug Administration and can be used for both girls and boys. It is important that as many people as possible in the recommended age group get vaccinated. Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, Centers for Disease Control and Prevention, Advisory Committee on Immunization Practices, ACIP specifies different dosing schedules, http://www.cdc.gov/vaccinesafety/Vaccines/HPV/Index.html, http://www.cdc.gov/vaccines/programs/vfc/index.html, U.S. Department of Health and Human Services, infections with HPV 16 and 18 decreased by 83% among girls aged 15–19 years and by 66% among women aged 20–24 years at up to 8 years after vaccination began, diagnoses of anogenital warts decreased by 67% among girls aged 15–19 years and by 54% among women aged 20–24 years at up to 9 years after vaccination began. HPV is known to cause cancers of the throat, cervix, vulva, … More information is available from the CDC at http://www.cdc.gov/vaccinesafety/Vaccines/HPV/Index.html. HPV vaccination does not lose the ability to protect against new HPV infections over time. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. BMC Infectious Diseases 2013; 13:140. Vaccines are available to help prevent infection by certain types of HPV and some of the cancers linked to those types. The HPV vaccine prevents infection by the HPV types responsible for most cervical cancers. These problems are similar to those commonly experienced with other vaccines. Also, vaccination is the approved public health intervention for reducing the risk of developing HPV-associated cancers at sites other than the cervix. This is to avoid confusing the symptoms of the illness with the response to the vaccine. Three doses are recommended for people with weakened immune systems aged 9 through 26 years. Analyses of data from women participating in a clinical trial of Cervarix found that this vaccine can protect women against persistent HPV 16 and 18 infections in the anus (14) and the oral cavity (15). Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. The FDA and CDC have reminded health care providers that, to prevent falls and injuries, all vaccine recipients should remain seated or lying down and be closely observed for 15 minutes after vaccination. ACIP specifies different dosing schedules, depending on the age of the individual (5). Also known by the brand name Gardasil 9, the HPV vaccine protects against: HPV types 16 and 18 — the 2 types that cause 80% of cervical cancer cases. Countries using HPV vaccine in national immunization schedule and planned introductions, May 2013. HPV vaccination in this age range provides less benefit, as more people have already been exposed to HPV. Jemal A, Simard EP, Dorell C, et al. All three vaccines prevent infection with HPV types 16 and 18, two high-risk HPVs that cause about 70% of cervical cancers and an even higher percentage of some of the other HPV-caused cancers (1, 2). Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: A randomized trial. Ages for Vaccination • Minimum age: 9 years • Routine age: 11-12 years • Recommended through age 26 years if not vaccinated previously. HPV Vaccine Facts. Vaccines, like any medicine, can have side effects. HPV vaccines protect against a very common sexually transmitted virus called HPV or human papillomavirus. Many people who get HPV vaccine have no side effects at all. A large study using national data from women across Australia, where vaccination rates are high, found that one dose of HPV vaccine was as effective as two or three doses in preventing high-grade cervical lesions (28). Vaccine 2017; 35(43):5753-5755. With more than 12 years of data, we know that HPV vaccine offers long-lasting protection against HPV infection and HPV disease. Teens and young adults who start the series later, at ages 15 through 26 years, need three doses of HPV vaccine. Because HPV vaccines do not protect against all HPV types that can cause cancer, women who have been vaccinated are advised to follow the same screening recommendations as unvaccinated women. Up until 2017, there were two vaccines available (Gardasil and Gardasil 9). Journal of the National Cancer Institute 2013; 105(3):175-201. How many doses of the HPV vaccine are needed? An analysis of data from a community-based clinical trial of Cervarix in Costa Rica, where cervical cancer rates are high, found than even one dose of the vaccine caused the body to produce approximately nine times more antibodies against HPV than the body produces in response to a natural HPV infection, and those antibody levels persisted for at least 7 years (26). Gardasil HPV Vaccine (Recombinant Human Papillomavirus Quadrivalent Vaccine) is a vaccine synthesized using recombinant technology. Decline in in-patient treatments of genital warts among young Australians following the national HPV vaccination program. HPV vaccine prevents infection from the HPV types that cause over 90% of these cancers. For example, in Australia, where a high proportion of girls are vaccinated with Gardasil, the incidence of genital warts went down during the first 4 years of the vaccination program among young males—who were not being vaccinated at the time—as well as among young females (16). A randomized clinical trial is currently under way in Costa Rica to evaluate if a single dose of HPV vaccine is sufficient to protect against HPV infection (29, 30). MMWR Morbidity and Mortality Weekly Report 2016; 65:1405–1408.Â. All preteens need HPV vaccination, so they are protected from HPV infections that can cause cancer later in life. Ali H, Guy RJ, Wand H, et al. Centers for Disease Control and Prevention. However, these women should be told that the vaccination will not cure them of current HPV infections or treat the abnormal results of their Pap test (23). The active ingredients in the HPV vaccine are proteins that are … Hildesheim A, Gonzalez P, Kreimer AR, et al. Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment. American Journal of Obstetrics and Gynecology 2016; 215(2):212.e1-212.e15. More than 98% of recipients develop an antibody response to HPV types included in the respective vaccines 1 month after completing a full vaccination series. The most common problems have been brief soreness and other local symptoms at the injection site. The HPV vaccine is applicable to both males and females. La vaccination contre les infections à Papillomavirus humains (HPV) est recommandée pour toutes les jeunes filles de 11 à 14 ans. Background Infection with human papillomavirus (HPV) and diseases caused by HPV are common in boys and men. However, some adults age 27 through 45 years who are not already vaccinated may decide to get HPV vaccine after speaking with their doctor about their risk for new HPV infections and the possible benefits of vaccination. Locate one near you.external icon. If you don’t have a regular source of health care, federally funded health centers can provide services. All three vaccines prevent infection with HPV types 16 and 18, two high-risk HPVs that cause about 70% of cervical cancers and an even higher percentage of some of the other HPV-caused cancers (1, 2). Three vaccines that prevent infection with disease-causing HPV types are licensed for use in the United States: Gardasil®, Gardasil® 9, and Cervarix®. The human papillomavirus (HPV) vaccine is unique among vaccines because it can prevent cancer. Use of a 2-dose schedule for human papillomavirus vaccination — Updated recommendations of the Advisory Committee on Immunization Practices. Lancet 2017; 390(10108):2143-2159. HPV infections and cervical precancers (abnormal cells on the cervix that can lead to cancer) have dropped significantly since the vaccine has been in use in the United States.

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